1414375-85-1Relevant academic research and scientific papers
Synthesis of macrocycles that inhibit protein synthesis: Stereochemistry and structural based studies on sanguinamide B derivatives
Pietkiewicz, Adrian L.,Wahyudi, Hendra,McConnell, Jeanette R.,McAlpine, Shelli R.
supporting information, p. 6979 - 6982 (2015/02/05)
We report the synthesis of seven new sanguinamide B (SanB) analogues. Substitution of amino acids along the backbone of SanB and testing in HCT-116 colon cancer cell lines identified new biologically active SanB derivatives. These compounds establish a st
Synthesis, structurea-activity analysis, and biological evaluation of sanguinamide B analogues
Wahyudi, Hendra,Tantisantisom, Worawan,Liu, Xuechao,Ramsey, Deborah M.,Singh, Erinprit K.,McAlpine, Shelli R.
, p. 10596 - 10616 (2013/02/22)
We report the first synthesis of sanguinamide B analogues. Substituting N-methylated (N-Me) amino acids, glycine (Gly), and l-or d-phenylalanine (Phe) into the backbone of sanguinamide B showed that only l-and d-Phe residues controlled the macrocycle conf
