Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1414469-59-2

Post Buying Request

1414469-59-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1414469-59-2 Usage

Biological Activity

tae-1 is an inhibitor of amyloid-β fibril formation and aggregation.alzheimer’s disease (ad), a progressive neurodegenerative disorder, is characterized by the cerebral accumulation of insoluble aggregates of amyloid-β peptides (aβ). although the precise mechanisms governing neuronal loss remains ambiguous, toxicity resulting from aβ-activated pathways is evident.

in vitro

in a previous study, the authors examined the effects of tae-1 on differentiated human sh-sy5y neuronal cells grown in tissue culture. results showed that the stimulation of neuronal cellular process length and branching was noted. moreover, the increased synaptophysin suggested that tae-1 could stimulate synapse formation. increased expression of map2 was also observed, indicating that tae-1 promoted the differentiation of human neurons. in addition, targeted ache inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes. it was found that at increasing tae-1concentrations, there was a corresponding decrease in the ache activity resulting in reduced amount of oxidizable thiocholine. the ic50 value was found to be 0.465 μm for tae-1 [1].

IC 50

0.3 ± 0.02 μm for ache; 3.9 ± 0.2 μm for buche

references

[1] veloso aj, chow am, dhar d, tang dw, ganesh hv, mikhaylichenko s, brown ir, kerman k. biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of alzheimer's disease. acs chem neurosci. 2013 jun 19;4(6):924-9.

Check Digit Verification of cas no

The CAS Registry Mumber 1414469-59-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,4,4,6 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1414469-59:
(9*1)+(8*4)+(7*1)+(6*4)+(5*4)+(4*6)+(3*9)+(2*5)+(1*9)=162
162 % 10 = 2
So 1414469-59-2 is a valid CAS Registry Number.

1414469-59-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Sigma

  • (SML0967)  TAE-1  ≥98% (HPLC)

  • 1414469-59-2

  • SML0967-5MG

  • 1,107.94CNY

  • Detail
  • Sigma

  • (SML0967)  TAE-1  ≥98% (HPLC)

  • 1414469-59-2

  • SML0967-25MG

  • 4,469.12CNY

  • Detail

1414469-59-2Upstream product

1414469-59-2Downstream Products

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1414469-59-2