1414545-97-3Relevant academic research and scientific papers
Synthesis of 2,5-bis(hetero)aryl 4′-substituted 4,5′- bisoxazoles via copper(I)-catalyzed domino reactions of activated methylene isocyanides with 2-phenyl- and 2-(2-thienyl)-4-[(aryl/heteroaryl)(methylthio) methylene]oxazol-5(4 H)-ones
Yugandar, Somaraju,Acharya, Anand,Ila, Hiriyakkanavar
, p. 3948 - 3960 (2013/05/22)
An efficient straightforward synthesis of 2,5,4′-trisubstituted 4,5′-bisoxazoles via copper(I)-catalyzed domino reactions of 2-phenyl- and 2-(2-thienyl)-4-[(aryl/heteroaryl)methylene]-5-oxazolones with activated methylene isocyanides has been reported. The overall domino process comprised of formation of one C-C and two C-O bonds involves initial nucleophilic ring opening of oxazolones by cupriomethylene isocyanides followed by sequential construction of two oxazole rings in the presence of copper catalyst. The broad substrate scope and excellent functional group compatibility of the reaction has been demonstrated by employing a variety of heteroaryl- and aryl-substituted oxazolones and activated methylene isocyanides, yielding bisoxazoles with three potential points of diversity. A probable mechanism for this novel copper-catalyzed domino process has been proposed.
Synthesis of 2-phenyl-4,5-substituted oxazoles by copper-catalyzed intramolecular cyclization of functionalized enamides
Vijay Kumar,Saraiah,Misra,Ila
supporting information, p. 10752 - 10763 (2013/02/22)
An efficient two-step synthesis of 2-phenyl-4,5-substituted oxazoles involving intramolecular copper-catalyzed cyclization of highly functionalized novel β-(methylthio)enamides as the key step has been reported. These enamides are obtained by nucleophilic
