14146-78-2

Basic information

• Product Name: 4H-Pyrano[3,4-d]isoxazol-4-one,3,6-dimethyl-(8CI,9CI)
• Synonyms: 4H-Pyrano[3,4-d]isoxazol-4-one,3,6-dimethyl-(8CI,9CI)
• CAS NO: 14146-78-2
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.14608
• Product Categories: OXAZOLE
• Mol File: 14146-78-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4H-Pyrano[3,4-d]isoxazol-4-one,3,6-dimethyl-(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrano[3,4-d]isoxazol-4-one,3,6-dimethyl-(8CI,9CI)(14146-78-2)
• EPA Substance Registry System: 4H-Pyrano[3,4-d]isoxazol-4-one,3,6-dimethyl-(8CI,9CI)(14146-78-2)

Safety Data

• Hazardous Substances Data: 14146-78-2(Hazardous Substances Data)

Upstream product

• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 54107-16-3 (E)-3-(1-hydrazonoethyl) -4-hydroxy-6-methyl-2H-pyran-2-one 
• 54107-20-9 3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one semicarbazone 

Relevant articles and documents

Tricarbonylmethane Acylhydrazones: Reactions under Acylating Conditions and Formation of Fused Isoxazole Derivatives with Concomitant N-N Bond Cleavage

Reactivity of 3-(1-acylhydrazonoethyl)-2H-pyran-2-ones 1a-k and 4a-d towards various acetylating agents and nitrous acid, respectively, is studied.Treatment of dehydroacetic acid (DHA) (thio)acylhydrazones 1a, c, f with Ac2O/Et3N afforded the 3-(1-triacetylhydrazinoethenyl) derivative 3a.The analogous coumarin derivative 5 was obtained by treatment of acetylhydrazone 4a with AcCl/PhNMe2.With concomitant N-N bond cleavage acylhydrazones 1c-f were converted to the pyrano-isoxazole 6 by treatment with NaNO2/AcOH whereas coumarin derivative 4d was converted to the imine 4e. - Keywords: Hydrazones / Coumarins / Dehydroacetic acid (DHA) / Isoxazoles