141463-19-6Relevant articles and documents
Renin inhibitors containing C-termini derived from mercaptoheterocycles
Ashton,Cantone,Meurer,Tolman,Greenlee,Patchett,Lynch,Schorn,Strouse,Siegl
, p. 2103 - 2112 (2007/10/02)
A series of transition-state analogues having heterocyclythio C-termini has been synthesized and evaluated for inhibition of human renin. Addition of mercaptoheterocycles to a chiral Boc-amino epoxide intermediate led, after several steps, to the target [