1414846-99-3Relevant academic research and scientific papers
A general method for the enantioselective synthesis of α-chiral heterocycles
Le, Phong Q.,Nguyen, Thien S.,May, Jeremy A.
, p. 6104 - 6107 (2013/02/23)
The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er's are observed for a host of common heteroaryls.
