1414859-08-7Relevant academic research and scientific papers
Cobalt alkyl complexes of a new family of chiral 1,3-bis(2-pyridylimino) isoindolates and their application in asymmetric hydrosilylation
Sauer, Désirée C.,Wadepohl, Hubert,Gade, Lutz H.
, p. 12948 - 12958 (2013/02/22)
The synthesis of a new family of chiral tridentate monoanionic NNN-pincer ligands based on the 1,3-bis(2-pyridylimino)isoindoline (BPI) framework is reported. Ligands with substituents of varying steric demand were prepared starting from achiral and low priced materials. A kinetic enzymatic resolution was used as a key step for the preparation of enantiomerically pure ligands. In this way, both enantiomers of a given ligand could be produced enantioselectively (>99.5% ee). The corresponding cobalt alkyl complexes were obtained using a pyridine alkyl cobalt precursor complex and were applied in asymmetric hydrosilylation of several prochiral alkylaryl ketones with high yields (up to 100%) and enantioselectivity (up to 91% ee) to give the chiral alcohols after hydrolysis.
