1414866-67-3

Upstream product

• 13544-43-9 6-(trifluoromethyl)-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 1414866-84-4 1-(pyrimidin-2-yl)-6-(trifluoromethyl)-1H-indole 

Relevant academic research and scientific papers

Rhodium-catalyzed regioselective amidation of indoles with sulfonyl azides via C-H bond activation

Direct C-2 amidation of indoles was reported using sulfonyl azides as the amino source to release N2 as the single byproduct. This reaction exhibits high functional group tolerance and regioselectivity, providing a variety of 2-amino substituted indoles in high to excellent yield. The procedure is robust, reliable, and compatible with water and air.