1414876-67-7

Basic information

• Product Name: (R)-5,5-difluoro-4-[5-fluoro-2-(4-methoxy-benzyl)-1H-indol-6-yl]-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
• Synonyms: (R)-5,5-difluoro-4-[5-fluoro-2-(4-methoxy-benzyl)-1H-indol-6-yl]-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
• CAS NO: 1414876-67-7
• Molecular Weight: 403.404
• Mol File: 1414876-67-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-5,5-difluoro-4-[5-fluoro-2-(4-methoxy-benzyl)-1H-indol-6-yl]-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5,5-difluoro-4-[5-fluoro-2-(4-methoxy-benzyl)-1H-indol-6-yl]-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine(1414876-67-7)
• EPA Substance Registry System: (R)-5,5-difluoro-4-[5-fluoro-2-(4-methoxy-benzyl)-1H-indol-6-yl]-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine(1414876-67-7)

Safety Data

• Hazardous Substances Data: 1414876-67-7(Hazardous Substances Data)

Upstream product

• 1310350-45-8 (R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 
• 13540-76-6 3-(4-methoxyphenyl)prop-1-yne 
• 1310350-58-3 (R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine 

Relevant articles and documents

1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present inv