1414937-29-3Relevant academic research and scientific papers
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase
Mercey, Guillaume,Renou, Julien,Verdelet, Tristan,Kliachyna, Maria,Baati, Rachid,Gillon, Emilie,Arboléas, Mélanie,Loiodice, Mélanie,Nachon, Florian,Jean, Ludovic,Renard, Pierre-Yves
supporting information, p. 10791 - 10795 (2013/02/23)
Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline- pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. This study explores the structure-activity relationships of this new family of reactivators and shows that 1b-d are uncharged hAChE reactivators with a broad spectrum.
