1414941-30-2Relevant academic research and scientific papers
Concise synthesis of the macrocyclic core of rhizopodin by a heck macrocyclization strategy
Dieckmann, Michael,Rudolph, Sven,Dreisigacker, Sandra,Menche, Dirk
supporting information, p. 10782 - 10788 (2013/02/23)
A highly convergent synthesis of the central dimeric core of the potent antibiotic macrolide rhizopodin is reported. Notable features of the highly concise route include an effective preparation of the key C8-C22 building block based on an iridium-catalyzed Krische allylation and a chemoselective cross-coupling approach toward the macrocycle involving a highly advantageous Heck reaction for macrocyclization.
