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Usage

Uses

Used in Organic Synthesis:
2-Methyl-5-(trifluoromethyl)pyrazole-3-carbaldehyde is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with specific properties and functions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Methyl-5-(trifluoromethyl)pyrazole-3-carbaldehyde is utilized as a key intermediate for the synthesis of pharmaceuticals. Its presence in the molecular structure can influence the pharmacological activity and selectivity of the resulting compounds.
Used in Biological Research:
2-Methyl-5-(trifluoromethyl)pyrazole-3-carbaldehyde has been studied for its potential biological activities, such as its role as an enzyme inhibitor. This makes it a valuable compound for investigating the mechanisms of action and potential therapeutic applications in various diseases and conditions.
Used in Chemical Research:
As a pyrazole derivative with a trifluoromethyl group, 2-Methyl-5-(trifluoromethyl)pyrazole-3-carbaldehyde is of interest to researchers in the field of chemical research. Its unique properties and reactivity can provide insights into the development of new synthetic methods and the understanding of chemical reactions involving similar compounds.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 154471-65-5 1-methyl-3-trifluoromethylpyrazol 

Relevant academic research and scientific papers

Practical synthetic method for functionalized 1-methyl-3/5-(trifluoromethyl)-1H-pyrazoles

A new, high-yielding, and practical method for synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl- 5-(trifluoromethyl)-1H-pyrazole, key intermediates for important building blocks relevant to medicinal and agrochemistry, is developed. A one-step procedure for synthesis of the regioisomeric mixture of target pyrazoles was proposed starting from 4-ethoxy- 1,1,1-trifluoro-3-buten-2-one. The procedure for separation of this mixture was elaborated on the basis of the boiling point vs pressure diagram analysis. The efficient synthetic strategies for regioisomeric building blocks bearing CF3 groups at the 3rd and 5th positions were demonstrated. A set of 1-methyl-3-(trifluoromethyl)-1H-pyrazoles containing such a functional group as aldehyde, acid, boron pinacolate, lithium sulfinate, and sulfonyl chloride was synthesized based on lithiation of 1-methyl-3-(trifluoromethyl)- 1H-pyrazole in a flow reactor. Bromination of both 1-methyl-3-(trifluoromethyl)-1H-pyrazole and 1-methyl-5-(trifluoromethyl)-1Hpyrazole by NBS in mild conditions was performed. The introduction of the functional group at the 4th position of 1-methyl-5- (trifluoromethyl)-1H-pyrazole was illustrated by the optimized synthesis of the corresponding aldehyde and acid based on the Br-Li exchange in an appropriate bromide. Alternatively, the introduction of the functional group (acid and boron pinacolate) at the 5th position of 1-methyl-5-(trifluoromethyl)-1H-pyrazole was performed based on the direct ortho-metalation (DoM) reaction of 4- bromo-1-methyl-5-(trifluoromethyl)pyrazole followed by catalytic reductive debromination.