1414969-71-3

Basic information

• Product Name: C₁₈H₁₈N₄O₂S*ClH
• Synonyms: C₁₈H₁₈N₄O₂S*ClH
• CAS NO: 1414969-71-3
• Molecular Weight: 390.893
• Mol File: 1414969-71-3.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈N₄O₂S*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈N₄O₂S*ClH(1414969-71-3)
• EPA Substance Registry System: C₁₈H₁₈N₄O₂S*ClH(1414969-71-3)

Safety Data

• Hazardous Substances Data: 1414969-71-3(Hazardous Substances Data)

Upstream product

• 1414969-69-9 (S)-tert-butyl (1-((2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 

Relevant articles and documents

Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy

Indole-3-amides and dipeptides were produced from 2-aminobenzothiazoles using the PyBop peptide coupling reagent. These analogues were tested in anti-cancer cell viability assays against SH-SY5Y neuroblastoma and MDA-MB-231 breast adenocarcinoma cell lines, and were found to exhibit cytotoxic activities at concentrations ranging from 0.1 to 20 μM. These compounds were also found to act additively with a low dosage of 13-cis-retinoic acid in neuroblastoma cells. Then, using neuroblastoma cells transfected to stably overexpress the RARβ2 gene, a SAR was developed for the indole-3-amides. Real-time PCR was also used to demonstrate their RARβ2 agonistic activity.