1414972-67-0

Upstream product

• 1277192-87-6 2-phenyl-6-bromo-5,7,8-trimethyl-1,4-benzoxazinone 
• 1277192-89-8 6-bromo-3,4-dihydro-5,7,8-trimethyl-2-phenyl-2H-benzo[b][1,4]oxazine 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 1145873-67-1 2-phenyl-5,7,8-trimethyl-2H-1,4-benzoxazin-3(4H)-one 

Relevant academic research and scientific papers

Divergent synthesis of 2,6-diaryl-substituted 5,7,8-trimethyl-1,4- benzoxazines via microwave-promoted palladium-catalyzed Suzuki-Miyaura cross coupling and biological evaluation

An efficient palladium-catalyzed Suzuki-Miyaura cross-coupling protocol effected in a mixture of DME/water (2:1) enables the reaction of sterically hindered and electron rich 6-chloro or 6-bromo-1,4-benzoxazines(ones) with a variety of aryl, vinyl or alkylboronic acids. Coupling is effected with catalyst loading of 5 mol % using sealed-vessel microwave processing. The resulting compounds exhibit potent activity against Toxoplasma gondii tachyzoite proliferation.