1415022-44-4

Basic information

• Product Name: C₁₁H₈Cl₂N₂OS
• CAS NO: 1415022-44-4
• Molecular Weight: 287.169
• Mol File: 1415022-44-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₈Cl₂N₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₈Cl₂N₂OS(1415022-44-4)
• EPA Substance Registry System: C₁₁H₈Cl₂N₂OS(1415022-44-4)

Safety Data

• Hazardous Substances Data: 1415022-44-4(Hazardous Substances Data)

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 184097-39-0 3‐(1,3‐thiazol‐2‐yl)aniline 

Relevant articles and documents

Design, synthesis and biological evaluation of N-arylphenyl-2,2- dichloroacetamide analogues as anti-cancer agents

Our earlier research has shown that N-phenyl-2,2-dichloroacetamide analogues had much higher anti-cancer activity than the lead compound sodium dichloroacetate (DCA). In this current study, a variety of N-arylphenyl-2,2- dichloroacetamide analogues were synthesized via Suzuki coupling reaction and their anti-cancer activity was evaluated. The results showed that N-terphenyl-2,2-dichloroacetamide analogues had satisfactory anti-cancer activity. Among them, N-(3,5-bis(benzo[d][1,3]dioxol-5-yl)phenyl)-2,2- dichloroacetamide (6 k) had an IC50 of 2.40 μM against KB-3-1 cells, 1.04 μM against H460 cells and 1.73 μM against A549 cells.