1415036-61-1Relevant articles and documents
Design, synthesis, and bioevaluation of benzamides: Novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase
Peng, Da-Yong,Sun, Qi,Zhu, Xiao-Lei,Lin, Hong-Yan,Chen, Qiong,Yu, Ning-Xi,Yang, Wen-Chao,Yang, Guang-Fu
, p. 6739 - 6750 (2013/01/15)
Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. In this study, we conducted a structure-based design and successfully produced a series of new multi-site AChE inhibitors with a novel framewo