1415045-45-2

Upstream product

• 183158-34-1 2,3-dimethylphenylboronic acid 
• 1415046-67-1 2-(2,3-dimethylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 73540-76-8 N,N-diethylfuran-3-carboxamide 

Relevant academic research and scientific papers

C-H activation by amide chelation control: Ruthenium-catalyzed direct synthesis of 2-Aryl-3-furanamides

A new, catalytic methodology for the synthesis of heterobiaryls by the ruthenium-catalyzed C-H activation/cross-coupling of heterocyclic amides with aryl boroneopentylates is surveyed. From this survey, the highly regioselective reaction of furan-3-carboxamide to give 2-aryl-3-furanamides is optimized and generalized in scope with respect to the aryl boroneopentylate coupling partners. Established thereby is a one-step synthetic method which may supercede the broadly applied two-step directed ortho metalation (DoM)-cross coupling reaction involving cryogenic and strong base conditions and which has potential for further ortho and remote metalation chemistry.