1415098-91-7Relevant academic research and scientific papers
Stereoselective synthesis and biological evaluation of d-fagomine, d-3-epi-fagomine and d-3,4-epi-fagomine analogs from d-glyceraldehyde acetonide as a common building block
Díez, J. Alberto,Gálvez, José A.,Díaz-De-Villegas, María D.,Badorrey, Ramón,Bartholomew, Barbara,Nash, Robert J.
, p. 9278 - 9286 (2012)
The stereoselective synthesis of d-fagomine, d-3-epi-fagomine, and d-3-epi-fagomine analogs starting from readily available d-glyceraldehyde acetonide has been achieved. The synthesis involves diastereoselective anti-vinylation of its homoallylimine, ring-closing metathesis, and stereoselective epoxidation followed by regioselective ring-opening or stereoselective dihydroxylation. The lack of a strong activity as glycosidase inhibitors of these compounds could be advantageous for their therapeutic use as chaperones.
