141517-21-7 Usage
Description
Trifloxystrobin is a synthetic derivative of the naturally occurring strobilurins found in several genera of wood-decaying fungi such as Strobilurus tenacellus. It is a strobilurin foliar fungicide. Trifloxystrobin inhibits mitochondrial respiration by blocking electron transfer within the respirator chain. Therefore, trifloxystrobin is a potent inhibitor of 2 fungal spore germination and mycelial growth. It has a high level of activity against many fungal pathogens within the Ascomycete, Deuteromycete, Basidiomycete, and Oomycete classes.
Pests controlled by trifloxystrobin include grape and cucurbit powdery mildew, apple scab and powdery mildew, peanut leafspot, and brown patch of turfgrass. It could be applied to cereals, ornamental, vegetables (carrots, asparagus, cucurbits, fruiting vegetables, root vegetables (except radish)), fruits (apples, pears, grapes, strawberries) and tropical crops.
References
[1] http://sitem.herts.ac.uk/aeru/iupac/Reports/664.htm
[2] EPA Pesticide Fact Sheet
Chemical Properties
Off-White to Pale Beige Solid
Uses
Different sources of media describe the Uses of 141517-21-7 differently. You can refer to the following data:
1. Agricultural fungicide.
2. Trifloxystrobin is a broad-spectrum foliar fungicide used in plant pritection. Trifloxystrobin functions by inhibiting fungal spore germination.
Metabolism
Trifloxystrobin is described as “mesostemic” due to its
ability to redistribute to untreated plant parts through
vapor action, limited but effective cuticular penetration,
and translaminarmovement by diffusion (30). It is rainfast
by virtue of its high affinity for the waxy cuticular layer.
Toxicity evaluation
Trifloxystrobin has an acute oral LD50 > 5,000 and an
acute dermal LD50 > 2,000 mg/kg in rats. It is not a skin
or eye irritant, is nonmutagenic and nonteratogenic. It
shows rapid absorption and elimination in the rat. It has
no toxicity to birds in acute studies (LD50 > 2,000 mg/kg)
but has an LC50 of 0.015 mg/L in rainbow trout. The
bee LD50 = 200 μg/bee. Environmental fate studies show
it to be hydrolytically stable at pH 5, with a DT50 of
11.4 weeks at pH 7. It has a photolytic DT50 of 31.5 h at
pH 7 (25 ?C) in water, a soil adsorption coefficient (Koc) of
1,642-3,745 ml/g, and a soil DT50 of 5.4 days under field
conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 141517-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,5,1 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 141517-21:
(8*1)+(7*4)+(6*1)+(5*5)+(4*1)+(3*7)+(2*2)+(1*1)=97
97 % 10 = 7
So 141517-21-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H19F3N2O4/c1-13(14-8-6-9-16(11-14)20(21,22)23)24-29-12-15-7-4-5-10-17(15)18(25-28-3)19(26)27-2/h4-11H,12H2,1-3H3/b24-13+,25-18+
141517-21-7Relevant articles and documents
Synthesis of 8-substituted 5H,9H-6-oxa-7-azabenzocyclononene- 10,11- dione- 11-O-methyloximes, a new [1,2]-oxazonine ring system
Pascual, Alfons,Ziegler, Hugo,Trah, Stephan,Ertl, Peter,Winkler, Tammo
, p. 1381 - 1384 (2000)
Reaction of (2-bromomethyl-phenyl)-methoxyimino-acetic acid methyl ester 4 with oximes 1 in the presence of NaH/DMF yields 8-substituted 5H,9H-6-oxa- 7-aza-benzocyclononene-10,11-dione-11-O-methyloximes 3 together with the expected open chain compounds 2. Some spectroscopic data as well as synthetic and mechanistic aspects of the formation of the novel compounds 3 are discussed. (C) 2000 Elsevier Science Ltd.
Preparation method of trifloxystrobin
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Paragraph 0027-0037, (2020/07/12)
The invention discloses a preparation method of trifloxystrobin. The method comprises the following steps: step 1, carrying out ultrasonic reaction on 3-trifluoromethylacetophenone oxime and (E)-2-(2'-bromomethyl phenyl)-2- carbonylacetic acid methyl ester -O-methylketone oxime in the presence of an acid-binding agent and an organic solvent; step 2, after finishing of the reaction, performing filtering to remove solids, performing washing with water, and carrying out reduced pressure distillation to remove a solvent to obtain a trifloxystrobin crude product; and step 3, recrystallizing a trifloxystrobin crude product with a low-polarity organic solvent, prforming filtering and drying to obtain a trifloxystrobin finished product. Compared with the traditional preparation method, the preparation method disclosed by the invention has the beneficial effects that firstly, an ultrasonic reaction instrument is adopted for reaction, and a low-boiling-point solvent is used for replacing a high-boiling-point reaction solvent, so that the production safety of the product is improved; secondly, the preparation method provided by the invention uses an ultrasonic reaction instrument for reaction, so that the reaction time is greatly shortened, the raw material conversion rate is high, the impurity content is obviously reduced; meanwhile, the production efficiency and the purity of the trifloxystrobin product are improved.
Trifloxystrobin and preparation method of intermittent thereof
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Paragraph 0098-0101, (2018/12/13)
The invention relates to a preparation method of trifloxystrobin. Preparation reaction of the trifloxystrobin is as shown in the description, wherein R is selected from C2-C5 linear alkyl or C3-C5 branched alkyl; in bromination reaction, a brominating agent is selected from NBS or 1,3-dibromo-5,5-dimethylhydantoin.
