1415221-68-9Relevant academic research and scientific papers
Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
Champeil, Elise,Paz, Manuel M.,Lukasiewicz, Elaan,Kong, Wan S.,Watson, Stephanie,Sapse, Anne-Marie
supporting information, p. 7198 - 7200 (2013/01/15)
We report here the synthesis of two amino precursors for the production of mitomycin C and 10-decarbamoylmitomycin C DNA adducts with opposite stereochemistry at C-1. The triamino mitosene precursors were synthesized in 5 steps from mitomycin C. In addition synthesis of the major mitomycin C-DNA adduct has been accomplished via coupling of a triaminomitosene with 2-fluoro-O6-(2-p-nitrophenylethyl)deoxyinosine followed by deprotection at the N2 and O6 positions.
