1415313-20-0

Usage

Uses

Used in Organic Synthesis:
(2E)-3-(4-fluorophenyl)-1-(3-nitrophenyl)prop-2-en-1-one is used as a synthetic intermediate for the creation of more complex organic molecules. Its distinct functional groups allow for various chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical field, (2E)-3-(4-fluorophenyl)-1-(3-nitrophenyl)prop-2-en-1-one is used as a building block for the development of new drugs. Its fluorophenyl and nitrophenyl groups can be key structural elements that contribute to the pharmacological properties of potential medicinal agents.
Used in Materials Science:
(2E)-3-(4-fluorophenyl)-1-(3-nitrophenyl)prop-2-en-1-one may also find applications in materials science. Its unique structure could be utilized in the design and synthesis of novel materials with specific properties, such as polymers with tailored characteristics for various applications.

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Relevant academic research and scientific papers

Structural, third-order optical nonlinearities and figures of merit of (E)-1-(3-substituted phenyl)-3-(4-fluorophenyl) prop-2-en-1-one under CW regime: New chalcone derivatives for optical limiting applications

In the present work, the crystal structures and third-order nonlinear optical (NLO) properties of two novel chalcone derivatives, (E)-1-(3-bromophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (F3BC) and (E)-1-(3-nitrophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (F3NC) have been experimentally investigated. Both chalcones were synthesized by Claisen–Schmidt condensation reaction. The single-crystals were obtained from slow evaporation solution growth method and were structurally characterized by single-crystal X-ray diffraction. Both studied crystals are crystallized in centrosymmetric space groups. The existence of C[sbnd]H?π interactions in F3BC and C[sbnd]H?O and C[sbnd]H?F hydrogen interactions in F3NC play important roles in creating supramolecular structures. The linear optical absorption coefficient (α) of F3BC and F3NC were analyzed by UV–Vis–NIR spectral analysis and the optical band gaps (Eg) were estimated. TG-DTA analysis revealed that the F3NC crystal has higher thermal stability than F3BC crystal. The third-order nonlinear optical properties of these crystals were studied in solution using Z-scan technique with a continuous wave (CW) DPSS laser operating at 532?nm wavelength. The molecules reveal a strong third-order nonlinear absorption (NLA) and negative nonlinear refraction (NLR). The calculated values of nonlinear absorption coefficient β, nonlinear refraction coefficient n2 and third-order nonlinear susceptibility χ(3) were found to be of the order of 10?5?cm/W, 10?8?cm2/W and 10?6?esu, respectively. The value of the two-photon absorption (2?PA) cross section at 532?nm for both chalcones is of the order of 108 GM. These crystals also exhibited optical limiting (OL) properties under CW laser excitation.

Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma

Chalcones share some structural similarities with GW-1929, a highly-selective and potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). In this study, we tested 53 structurally diverse chalcones to identify characteristics essential for PPARγ activation in a GAL4-based transactivation assay. This screen identified several novel chalcone agonists of PPARγ. Our results indicate that chalcones with an electron rich group or sterically large groups such as naphthyl on the carbonyl side tend to activate PPARγ. The absence of any strict structural or electronic requirements suggests that the flexibility of the PPARγ ligand binding pocket may allow binding of diverse chalcones with some preference for a slightly larger electron-rich group on the carbonyl side. We predict that further structure-activity relationship studies on chalcones with naphthalene or electron-rich groups near the carbonyl moiety will lead to the development of more potent PPARγ agonists.