Cas 1415319-59-3,4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile

1415319-59-3

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Basic information

Product Name: 4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile
Synonyms: 4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile
CAS NO:1415319-59-3
Molecular Formula:
Molecular Weight: 730.878
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile(CAS DataBase Reference)
NIST Chemistry Reference: 4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile(1415319-59-3)
EPA Substance Registry System: 4,4'-((6,6'-(propane-1,3-diylbis(azanediyl))bis(4-(mesitylamino)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile(1415319-59-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1415319-59-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1415319-59-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,5,3,1 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1415319-59:
(9*1)+(8*4)+(7*1)+(6*5)+(5*3)+(4*1)+(3*9)+(2*5)+(1*9)=143
143 % 10 = 3
So 1415319-59-3 is a valid CAS Registry Number.

1415319-59-3Upstream product

244272-07-9 4-((4-chloro-6-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile

1415319-59-3Downstream Products

1415319-59-3Relevant academic research and scientific papers

Novel triazine dimers with potent antitrypanosomal activity

Venkatraj, Muthusamy,Salado, Irene G.,Heeres, Jan,Joossens, Jurgen,Lewi, Paul J.,Caljon, Guy,Maes, Louis,Van der Veken, Pieter,Augustyns, Koen

, p. 306 - 319 (2017/12/07)

Human African trypanosomiasis (HAT), also known as sleeping sickness is a parasitic disease transmitted by the bite of the ‘Glossina’ insect, commonly known as the tsetse fly. This disease affects mostly poor populations living in remote rural areas of Africa. Untreated, it is usually fatal. Currently, safe and effective treatments against this disease are lacking. Phenotypic screening of triazine non-nucleoside HIV-1 reverse transcriptase inhibitors (monomers) resulted in potent and selective antitrypanosomal compounds. This serendipitous discovery and the presence of dimers in many compounds active against these neglected tropical diseases prompted us to investigate antitrypanosomal activity of triazine dimers. Optimization of the triazine dimers resulted in 3,3’-(((ethane-1,2-diylbis(azanediyl))bis(4-(mesityloxy)-1,3,5-triazine-6,2-diyl))bis(azanediyl))dibenzonitrile (compound 38), a compound with very potent in vitro and moderate in vivo antitrypanosomal activity.

DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES

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Paragraph 0242; 0245; 0255; 0263; 0264, (2014/11/11)

The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These compounds show activity against the causative infective agents of infectious diseases s

DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES

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Page/Page column 33; 34; 35; 36; 37, (2013/05/23)

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