1415341-89-7Relevant academic research and scientific papers
To replace the double-aryl cycloalkyl derivatives and its preparation method and application
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Paragraph 0089-0091; 0096; 0122; 0123; 0124; 0125; 0126, (2017/07/01)
The invention provides a substituent bis-aryl methylene naphthenic base derivative with the structure of a general formula I, as well as medical salt or hydrate thereof. The class of compound can be used as micromolecule tubulin inhibitor, has a canalicul
Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors
Aziz, Jessy,Brachet, Etienne,Hamze, Abdallah,Peyrat, Jean-Fran?ois,Bernadat, Guillaume,Morvan, Estelle,Bignon, Jér?me,Wdzieczak-Bakala, Joanna,Desravines, Déborah,Dubois, Joelle,Tueni, Marie,Yassine, Ahmad,Brion, Jean-Daniel,Alami, Mouad
, p. 430 - 442 (2013/02/23)
The synthesis and structure-activity relationships associated with a series of 1,1-diarylethylene tubulin polymerization inhibitors 3 and 4 are described. The key step for their preparation involves a palladium-catalyzed coupling of N-arylsulfonylhydrazon
