1415357-66-2Relevant academic research and scientific papers
Highly enantioselective Rh-catalyzed carboacylation of olefins: Efficient syntheses of chiral poly-fused rings
Xu, Tao,Ko, Haye Min,Savage, Nikolas A.,Dong, Guangbin
supporting information, p. 20005 - 20008 (2013/02/22)
Here we report the first highly enantioselective Rh-catalyzed carboacylation of olefins via C-C bond activation of benzocyclobutenones. Good yields and excellent enantioselectivities (92-99% ee, 14 examples) were obtained for substrates with various steric and electronic properties. In addition, fully saturated poly-fused rings were prepared from the carboacylation products through a challenging catalytic reductive dearomatization approach. These investigations provide a distinct way to prepare chiral carbon frameworks that are nontrivial to access with conventional methods.
