1415404-86-2Relevant academic research and scientific papers
Cytotoxic potential of dispirooxindolo/acenaphthoquino andrographolide derivatives against MCF-7 cell line
Chakraborty, Debanjana,Maity, Arindam,Jain, Chetan K.,Hazra, Abhijit,Bharitkar, Yogesh P.,Jha, Tarun,Majumder, Hemanta K.,Roychoudhury, Susanta,Mondal, Nirup B.
, p. 702 - 707 (2015/04/27)
Dispiro andrographolide derivatives have been prepared from isatin/acenaphthoquinone, N-benzyl glycine and andrographolide via azomethine ylide cycloaddition reaction. The cytotoxic effect of the synthesized molecules has been studied against MCF-7 breast
Regio- and stereoselective synthesis of a library of bioactive dispiro-oxindolo/acenaphthoquino andrographolides via 1,3-dipolar cycloaddition reaction under microwave irradiation
Hazra, Abhijit,Bharitkar, Yogesh P.,Chakraborty, Debanjana,Mondal, Susanta Kumar,Singal, Nupur,Mondal, Shyamal,Maity, Arindam,Paira, Rupankar,Banerjee, Sukdeb,Mondal, Nirup B.
, p. 41 - 48 (2013/03/13)
Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/N-benzyl glycine to l-proline changes the regiochemistry. A representative library of 40 compounds along with in vitro anticancer evaluation is reported.
