141541-17-5Relevant articles and documents
SYNTHESIS OF 4,5,6,7-TETRAPHENYL-8(SUBSTITUTED-3(2H)-PHTHALAZINONE DERIVATIVES WITH POTENTIAL ANTIHYPERTENSIVE ACTIVITY
Yassin, F. A.,El-Safty, M. A.,Bayoumy, B. E.,Farargy, A. F. El
, p. 201 - 208 (2007/10/03)
The interaction of tetraphenylphthalic anhydride with o-chlorotoluene under Friedel-Crafts conditions gives 2-(4-chloro-3-methyl)benzoyl-3,4,5,6-tetraphenyl benzoic acid (1) which on reaction with hydrazine derivatives gave phthalazinones 2a-d. The behaviour of 2a towards carbon electrophiles and carbon nucleophiles has been investigated. The chlorophthalazinone 3s has been also synthesised through the action of PCl5/POCl3 on 2a. The behaviour of 3s towards nitrogen, and oxygen nucleophiles also has been described.