1415425-08-9Relevant academic research and scientific papers
TiCl2·2H2O catalyzed one-pot synthesis of highly functionalized tetrahydropiperidines and evaluation of their antimicrobial activities
Abbasi, Mohsen,Seyedi, Seyed Mohammad,Sadeghian, Hamid,Akhbari, Maryam,Enayaty, Mohammadreza,Shiri, Ali
, p. 117 - 121 (2016)
One-pot condensation reaction of ethyl acetoacetate, various substituted benzaldehydes and anilines in the presence of TiCl2·2H2O yields highly functionalized tetrahydropiperidines. Atom economy, efficiency, and short reaction times are the advantages of the method, which is carried out under mild conditions using easily accessible and inexpensive chemicals. The antimicrobial activity of the synthesized products was evaluated against three Gram-positive and three Gram-negative bacteria, a yeast and a fungus strain using disc diffusion and minimum inhibitory concentration methods.
Antimony trichloride as a mild and accessible catalyst for the one-pot synthesis of tetrahydropyridines at room temperature
Mohammadi, Seddigheh,Ghazanfari, Dadkhoda,Karimi-Jaberi, Zahed
, p. 825 - 829 (2018/04/09)
Since tetrahydropyridine and its derivatives as heterocyclic compounds have many biological and pharmaceutical applications in industries, finding an acceptable synthesis yield by an appropriate catalyst is essential. In this study, the synthesis of tetra
Ruthenium chloride catalysed multicomponent reaction for efficient and onepot synthesis of functionalised tetrahydropiperidines at room temperature
Mohammadi, Sedigheh,Abbasi, Mohsen
, p. 123 - 126 (2015/06/16)
Ruthenium chloride plays the role of a Lewis acid catalyst for the one-pot three-component synthesis of highly functionalised tetrahydropiperidines from aromatic aldehydes, anilines and ethyl acetoacetate in ethanol at ambient temperature without any ligand or activator. The simple experimental procedure, high yields of products, no need for column chromatography, and short reaction times compared to other catalysts are some of the advantages of this method.
Design of ionic liquid sulfonic acid pyridinium hydrogen sulfate as an efficient, eco-friendly, and reusable catalyst for one-pot synthesis of highly functionalized tetrahydropyridines
Mohammadi, Sedigheh,Abbasi, Mohsen
, p. 8877 - 8890 (2015/03/31)
Novel ionic liquid sulfonic acid pyridinium hydrogen sulfate ([Pyridine-SO3H]HSO4) is synthesized and characterized by various techniques such as FT-IR, 1H NMR, 13C NMR, TG, DTG, as well as mass spectra. This ionic liquid is used as an efficient, homogeneous, and recyclable catalyst for one-pot synthesis of highly functionalized tetrahydropyridines from the three-component condensation of aromatic aldehydes, ethyl acetoacetate, and substituted anilines under solvent-free conditions. The main advantages of this protocol are the short reaction time, high yields, mild and clean conditions, and several reuse times without noticeably decreasing the catalytic activity.
LaCl3·7H2O as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions
Umamahesh, Balijapalli,Sathesh, Venkatesan,Ramachandran, Gunasekar,Sathishkumar, Munusamy,Sathiyanarayanan, Kulatu
experimental part, p. 895 - 900 (2012/10/07)
The three-component one-pot synthesis of highly functionalized piperidine derivatives was carried out by condensing 1,3-dicarbonyl compounds with aromatic aldehydes and aniline using a catalytic amount (10 mol%) of LaCl 3·7H2O in methanol at room temperature. The main features of current protocol include easy work up, mild reaction conditions, good yields and high atom economy. Springer Science+Business Media, LLC 2012.
