1415425-26-1

Basic information

• Product Name: (E)-3-(dibenzo[b,d]furan-2-yl)-2-((4-fluorophenoxy)methyl) acrylic acid
• Synonyms: (E)-3-(dibenzo[b,d]furan-2-yl)-2-((4-fluorophenoxy)methyl) acrylic acid
• CAS NO: 1415425-26-1
• Molecular Weight: 362.357
• Mol File: 1415425-26-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-(dibenzo[b,d]furan-2-yl)-2-((4-fluorophenoxy)methyl) acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(dibenzo[b,d]furan-2-yl)-2-((4-fluorophenoxy)methyl) acrylic acid(1415425-26-1)
• EPA Substance Registry System: (E)-3-(dibenzo[b,d]furan-2-yl)-2-((4-fluorophenoxy)methyl) acrylic acid(1415425-26-1)

Safety Data

• Hazardous Substances Data: 1415425-26-1(Hazardous Substances Data)

Upstream product

• 5397-82-0 dibenzofuran-2-carbaldehyde 
• 1421756-43-5 C₂₃H₁₇FO₄ 
• 1415425-20-5 (Z)-methyl 2-(bromomethyl)-3-(dibenzo[b,d]furan-2-yl)acrylate 

Relevant articles and documents

Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel dibenzofuran embodied homoisoflavonoids via Baylis-Hillman reaction

A novel series of natural product like dibenzofuran embodied homoisoflavonoids [(E)-3-(dibenzo[b,d]furan-2-ylmethylene)chroman-4-ones] designed by molecular hybridization were synthesized in very good yields via a sequence of reactions involving base catalyzed Baylis-Hillmann (BH) reaction of 2-dibenzofuran carboxaldehyde and methyl acrylate; bromination of BH adduct; condensation of resulted allylic bromide with substituted phenols or 2-dibenzofuranol followed by cyclization. Among the all 11 new compounds screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB), (E)-3-(dibenzo[b,d]furan-2-ylmethylene)-6- fluorochroman-4-one (7f) and (E)-3-(dibenzo[b,d] furan-2-ylmethylene)-6- fluorochroman-4-one (7g) were found to be active with MIC 12.5 μg/mL.