1415460-68-2Relevant academic research and scientific papers
The development of carbon-carbon bond forming reactions of aminal radicals
Schiedler, David A.,Vellucci, Jessica K.,Lu, Yi,Beaudry, Christopher M.
, p. 1448 - 1465 (2015/02/19)
Aminal radicals were generated and used in synthetic reactions for the first time. Aminal radicals are formed from aminals by radical translocation using AIBN and a stoichiometric hydrogen atom donor, or by SmI2 reduction of N-acyl amidines or amidinium ions in the presence of a proton source. Aminal radicals were found to participate in inter- and intramolecular C-C bond forming reactions with electron deficient alkenes. Chemical yields were as high as 99%.
Reductive synthesis of aminal radicals for carbon-carbon bond formation
Schiedler, David A.,Lu, Yi,Beaudry, Christopher M.
supporting information, p. 1160 - 1163 (2014/03/21)
Aminal radicals were generated by reduction of the corresponding amidine or amidinium ion. The intermediate radicals participate in C-C bond-forming reactions to produce fully substituted aminal stereocenters. No toxic additives or reagents are required. More than 30 substrate combinations are reported, and chemical yields are as high as 99%.
Formation of carbon-carbon bonds using aminal radicals
Schiedler, David A.,Vellucci, Jessica K.,Beaudry, Christopher M.
supporting information, p. 6092 - 6095 (2013/02/23)
Aminal radicals were generated by radical translocation processes. For the first time, it is shown that they participate in carbon-carbon bond forming reactions. Either stannane or silane hydrogen atom donors are suitable for the reaction. More than 30 su
