1415466-08-8

Basic information

• Product Name: 5,6,7-trimethoxy-2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one
• Synonyms: 5,6,7-trimethoxy-2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one
• CAS NO: 1415466-08-8
• Molecular Weight: 338.363
• Mol File: 1415466-08-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6,7-trimethoxy-2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7-trimethoxy-2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one(1415466-08-8)
• EPA Substance Registry System: 5,6,7-trimethoxy-2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one(1415466-08-8)

Safety Data

• Hazardous Substances Data: 1415466-08-8(Hazardous Substances Data)

Upstream product

• 1415465-73-4 3-phenyl-5-(3,4,5-trimethoxyphenyl)-4,5dihydropyrazole-1-carbaldehyde 
• 127034-55-3 3,4,5-trimethoxychalcone 

Relevant articles and documents

Alternate synthesis route of 2-(substituted phenyl)-3,3a-dihydro-8H- pyrazolo[5,1-a[isoindol-8-ones via chalcone-based n-formyl-pyrazolines

An alternate approach to 2-(substituted phenyl)-3,3a-dihydro-8H-pyrazolo[5, l-a] isoindol-8-ones via chalcone-based N-formyl-pyrazolines is described. N-Formyl-pyrazolines were prepared in excellent yield (81-96%) by the reaction of chalcones with hydrazine hydrate in the presence of formic acid, which undergoes intramolecular Friedel-Crafts acylation in the presence of trifluoroacetic acid (TFA) as a catalyst to afford functionalized 2-(substituted phenyl)-3,3a-dihydro-8H-pyrazolo[5,1-a]isoindol-8-ones in good to excellent yield (74-94%) at reflux in acetonitrile. Our synthetic route avoids expensive reagents and significantly improves yields.