1415488-75-3Relevant academic research and scientific papers
Synthesis and anti-inflammatory evaluation of novel benzimidazole and imidazopyridine derivatives
Chen, Gaozhi,Liu, Zhiguo,Zhang, Yali,Shan, Xiaoou,Jiang, Lili,Zhao, Yunjie,He, Wenfei,Feng, Zhiguo,Yang, Shulin,Liang, Guang
supporting information, p. 69 - 74 (2013/03/14)
Sepsis, an acute inflammatory disease, remains the most common cause of death in intensive care units. A series of benzimidazole and imidazopyridine derivatives were synthesized and screened for anti-inflammatory activities, and the imidazopyridine series showed excellent inhibition of the expression of inflammatory cytokines in LPS-stimulated macrophages. Compounds X10, X12, X13, X14, and X15 inhibited TNF-α and IL-6 release in a dose-dependent manner, and X12 showed no cytotoxicity in hepatic cells. Furthermore, X12 exhibited a significant protection against LPS-induced septic death in mouse models. Together, these data present a series of new imidazopyridines with potential therapeutic effects in acute inflammatory diseases.
