1415509-25-9

Basic information

• Product Name: C₁₈H₁₆N₆O₂S
• Synonyms: C₁₈H₁₆N₆O₂S
• CAS NO: 1415509-25-9
• Molecular Weight: 380.43
• Mol File: 1415509-25-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆N₆O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆N₆O₂S(1415509-25-9)
• EPA Substance Registry System: C₁₈H₁₆N₆O₂S(1415509-25-9)

Safety Data

• Hazardous Substances Data: 1415509-25-9(Hazardous Substances Data)

Upstream product

• 4498-72-0 1-(1H-indazol-3-yl)ethanone 
• 1415509-13-5 (E)-3-(dimethylamino)-1-(1-methyl-1H-indazol-3-yl)prop-2-en-1-one 
• 5626-85-7 4-guanidinobenzenesulfonamide 

Relevant articles and documents

Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents

A series of N-phenyl-imidazo[4,5-b]pyridin-2-amines, 4-indazolyl-N- phenylpyrimidin-2-amines and N-phenyl-4-pyrazolo[3,4-b]pyridin-pyrimidin-2- amines have been synthesized. Their anti-proliferative activities were tested in HCT-116 human colon carcinoma and MCF-7 breast carcinoma cell lines. Many exhibited potent anti-proliferative and CDK9 inhibitory activities. A lead compound 18b demonstrated the ability to reduce the level of Mcl-1 anti-apoptotic protein, to activate caspase 3/7 and induce cancer cell apoptosis.