141554-45-2

Upstream product

• 108926-37-0 (4'S,5'R,6'R)-4-6'-1,4-dihydroxy-2-methyl-3-methylene-butyryl-5'-tert-butyldimethylsiloxy-1'-3'-dioxan-4'-yl-2,6-piperidinedione 
• 113425-71-1 4-{(4S,5R,6S)-6-[(R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-but-3-enoyl]-5-hydroxy-[1,3]dioxan-4-yl}-piperidine-2,6-dione 
• 102487-45-6 4-((4S,5R,6R)-5-Hydroxy-6-hydroxymethyl-[1,3]dioxan-4-yl)-piperidine-2,6-dione 
• 126267-16-1 (1R,2S,6R,7R,9S)-(-)-9-(tert-butyldiphenylsilyloxy)-6-<(1R,2R)-1-hydroxy-2-methyl-3-methylene-4-(tert-butyldimethylsilyloxy)butyl>-3,5,8-trioxa-10-azatricyclo<7.3.1.0^2.7>tridecan-11-one 
• 126267-16-1 (1R,2S,6R,7R,9S)-(+)-9-(tert-butyldiphenylsilyloxy)-6-<(1S,2R)-1-hydroxy-2-methyl-3-methylene-4-(tert-butyldimethylsilyloxy)butyl>-3,5,8-trioxa-10-azatricyclo<7.3.1.0^2.7>tridecan-11-one 
• 62097-05-6 ethyl (E)-2-(bromomethyl)but-2-enoate 
• 113425-71-1 4-{(4R,5S,6R)-6-[(S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-but-3-enoyl]-5-hydroxy-[1,3]dioxan-4-yl}-piperidine-2,6-dione 
• 104777-85-7 4-[(4R,5S,6R)-6-[(S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-but-3-enoyl]-5-(3,4-dimethoxy-benzyloxy)-[1,3]dioxan-4-yl]-piperidine-2,6-dione 
• 104777-84-6 4-[(4R,5S,6S)-6-[(1S,2S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-hydroxy-2-methyl-but-3-enyl]-5-(3,4-dimethoxy-benzyloxy)-[1,3]dioxan-4-yl]-piperidine-2,6-dione 
• 104777-87-9 (4R,5S,6R)-5-(3,4-Dimethoxy-benzyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxane-4-carbaldehyde 
• 104777-88-0 4-[(4R,4aS,8aS)-6-(3,4-Dimethoxy-phenyl)-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]-piperidine-2,6-dione 
• 104777-86-8 4-[(4R,5S,6S)-5-(3,4-Dimethoxy-benzyloxy)-6-hydroxymethyl-[1,3]dioxan-4-yl]-piperidine-2,6-dione 
• 100641-08-5 (Z)-2-<(trimethylsilyl)methyl>-but-2-ene-1-ol 
• 104777-89-1 (Z)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trimethylsilanylmethyl-but-2-ene 

Relevant academic research and scientific papers

Total Synthesis of (+/-)-Sesbanimide A and B

The total synthesis of sesbanimide A (1) and B (2) is reported which features (a) the reaction of cyclopentadiene with glyoxylic acid leading to the useful bicyclic lactone building block 3 and (b) the use of 2.5 mol/ dm-3 lithium perchlorate i

An alternative synthesis of (+)-sesbanimide A

D-(+)-xylose has been converted to (+)-sesbanimide A in sixteen steps.The synthetic scheme involves an ususual tricyclic silylated derivative (9a) of the monobenzoylated product of the earlier described glutarimide intermediate (7).Compound 9a is a pivotal intermediate for the construction of ring C of (+)-sesbanimide A.

A Total Synthesis of (-)-Sesbanimide A

The molecule (-)-sesbanimide A (1), the optical antipode of the potent cytotoxic natural product (+)-sesbanimide A (2), has been prepared starting from the aldehyde 3 via a brief and efficient reaction pathway.