1415559-79-3Relevant academic research and scientific papers
Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile
Adili, Alafate,Tao, Zhong-Lin,Chen, Dian-Feng,Han, Zhi-Yong
, p. 2247 - 2250 (2015/03/04)
2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes with excellent yields and enantioselectivities. Moreover, this reaction can be performed in up to 6 mmol scale without any noticeable loss of yield and stereoselectivity. This journal is
Enantioselective addition of boronates to o -quinone methides catalyzed by chiral biphenols
Luan, Yi,Schaus, Scott E.
supporting information, p. 19965 - 19968 (2013/02/22)
Chiral biphenols were found to catalyze the enantioselective asymmetric addition of aryl- or alkenylboronates to o-quinone methides. Substituted 2-styryl phenols were obtained in good yields (up to 95%) with high enantiomeric ratios (up to 98:2) in the pr
