1415569-78-6Relevant articles and documents
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
Oka, Yusuke,Yabuuchi, Tetsuya,Fujii, Yasuyuki,Ohtake, Hidenori,Wakahara, Shunichi,Matsumoto, Kayo,Endo, Mayumi,Tamura, Yunoshin,Sekiguchi, Yoshinori
, p. 7534 - 7538 (2012)
A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors. The modification of a high-throughput screening hit, compound 1, resulted in the identification of compounds 10 and 15, which displayed potent inhibitory activities in enzyme-based and cell-based assays.