1415606-11-9

Basic information

• Product Name: ethyl 1-phenyl-4-hydroxy-5-oxo-2-(4-trifluoromethylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate
• Synonyms: ethyl 1-phenyl-4-hydroxy-5-oxo-2-(4-trifluoromethylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate
• CAS NO: 1415606-11-9
• Molecular Weight: 391.347
• Mol File: 1415606-11-9.mol

Chemical Properties

• CAS DataBase Reference: ethyl 1-phenyl-4-hydroxy-5-oxo-2-(4-trifluoromethylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-phenyl-4-hydroxy-5-oxo-2-(4-trifluoromethylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate(1415606-11-9)
• EPA Substance Registry System: ethyl 1-phenyl-4-hydroxy-5-oxo-2-(4-trifluoromethylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate(1415606-11-9)

Safety Data

• Hazardous Substances Data: 1415606-11-9(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 62-53-3 aniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Relevant articles and documents

Green one-pot multicomponent synthesis of pyrrolidinones using planetary ball milling process under solvent-free conditions

This paper presents a novel and efficient protocol for the synthesis of pyrrolidinones using catalytic loading of 1,1'-butylenebis(3-sulfo-3H-imidazol-1-ium) hydrogen sulfate as a recyclable Br?nsted acid ionic liquid through ball milling process at room temperature under solvent-free conditions. The developed method provides good to excellent yields of various pyrrolidinones in environmentally friendly conditions. Furthermore, this efficient protocol displays a combination of the synthetic advantage of one-pot multicomponent reaction with ecological benefits and convenience of a mechanochemical procedure.

An Efficient Synthesis of Pyrrolidinone Derivatives in the Presence of 1,1′-Butylenebis(3-sulfo-3 H -imidazol-1-ium) Chloride

The catalytic efficiency of 1,1′-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid-functionalized ionic liquid was demonstrated for the synthesis of pyrrolidinone derivatives under mild conditions. The electronic effect of substituents on aniline derivatives was investigated. Further, a study on the structure-activity relationship of ionic liquids containing sulfonic groups for the synthesis of ethyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate was performed under optimal conditions. The results showed that the catalytic properties of ionic liquids containing two sulfonic or imidazole moieties with carbon spacers was superior to ionic liquids having one sulfonic or imidazole moiety with no carbon spacer.

Lactic acid as an invaluable bio-based solvent for organic reactions

Lactic acid was used, for the first time, as a bio-based green solvent to promote some organic reactions, such as three-component reactions of styrenes, formaldehyde and an active phenolic compound or N,N-dialkylacetoacetamides, three-component reactions