1415635-75-4

Upstream product

• 1415635-77-6 (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-ol 
• 1366246-41-4 (2S,3R,4R,Z)-3-((tert-butyldimethylsilyl)oxy)-8-((4-methoxybenzyl)oxy)-2,4-dimethyloct-6-enal 
• 1415635-83-4 (2S,3R,4R,Z)-3-((tert-butyldimethylsilyl)oxy)-N-methoxy-8-((4-methoxybenzyl)oxy)-N,2,4-trimethyloct-6-enamide 
• 1415635-82-3 (2S,3R,4R,Z)-3-hydroxy-N-methoxy-8-((4-methoxybenzyl)oxy)-N,2,4-trimethyloct-6-enamide 
• 1415635-92-5 C₁₀H₁₁BrO₃ 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 1415635-81-2 (2S,3R,4R,Z)-3-hydroxy-8-((4-methoxybenzyl)oxy)-2,4-dimethyloct-6-enoic acid 
• 1385018-40-5 (R,Z)-6-((4-methoxybenzyl)oxy)-2-methylhex-4-enal 
• 1415635-78-7 (R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide 
• 1012367-44-0 (S)-N-methoxy-N,2-dimethylpent-4-enamide 
• 20626-61-3 (S)-2-methyl-4-pentenoic acid 
• 277297-37-7 (2S)-N-[1R,2R]-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethyl-4-pentenamide 

Downstream Products

• 1415635-86-7 (4S,5R,6R,7R,Z)-6-((tert-butyldimethylsilyl)oxy)-11-((4-methoxybenzyl)oxy)-5,7-dimethylundeca-1,9-dien-4-yl 2-((2R,3S)-2-hydroxy-3-methylpent-4-en-1-yl)-4,6-dimethoxybenzoate 

Relevant academic research and scientific papers

Synthesis of cruentaren A

Cruentaren A, an antifungal benzolactone produced by the myxobacterium Byssovorax cruenta, is highly cytotoxic against various human cancer cell lines and a highly selective inhibitor of mitochondrial F-ATPase. A convergent and efficient synthesis of cruentaren A is reported, based upon a diastereoselective alkylation, a series of stereoselective aldol reactions utilizing Myers' pseudoephedrine propionamide, an acyl bromide mediated esterification, and a ring-closing metathesis (RCM) as the key steps. The RCM reaction was applied for the first time toward the total synthesis of cruentaren A, which led to a convergent and efficient synthesis of the natural product.