1415669-05-4Relevant academic research and scientific papers
Parallel synthesis of structurally diverse aminobenzimidazole tethered sultams and benzothiazepinones
Dadiboyena, Sureshbabu,Nefzi, Adel
, p. 6897 - 6900 (2012)
A solid-phase methodology to construct aminobenzimidazole tethered sultams and benzothiazepinones from commercial amino acids, amines, carboxylic acids, and sulfonyl chlorides is described. Coupling of Fmoc-Cys(Trt)-OH to resin-bound aminobenzimidazole scaffold provided an essential precursor for the construction of a variety of seven membered benzofused cyclic sulfonamides and thiazepinones via palladium catalyzed Buchwald-Hartwig type intramolecular cyclization.
