1415669-27-0Relevant academic research and scientific papers
Nucleophilic fluorination of β-ketoester derivatives with HBF 4
Pasceri, Raffaele,Bartrum, Hannah E.,Hayes, Christopher J.,Moody, Christopher J.
supporting information, p. 12077 - 12079 (2013/01/16)
Treating readily available α-diazo-β-ketoesters with HBF 4 results in nucleophilic fluorination by the usually inert and stable tetrafluoroborate anion. The resulting α-fluoro-β-ketoesters are highly versatile synthetic intermediates, for example in the preparation of fluoro-heterocycles, as illustrated by the direct formation of fluoro-pyrimidines, -pyrazoles and -coumarins in a single step.
