1415686-22-4

Upstream product

• 1415686-17-7 (Z)-3-(4-((triisopropylsilyl)oxy)benzylidene)-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ol 
• 1415686-16-6 1-(2-iodo-1H-indol-3-yl)-4-(4-((triisopropylsilyl)oxy)phenyl)but-3-yn-2-ol 
• 550373-07-4 1-ethynyl-4-(triisopropylsilyloxy)benzene 
• 2200-91-1 4-ethynylphenol 
• 88075-18-7 4-(2-(trimethylsilyl)ethynyl)phenol 

Downstream Products

• 1415686-18-8 (E)-3-(4-((triisopropylsilyl)oxy)benzylidene)-3,4-dihydrocyclopenta[b]indol-2(1H)-one 
• 1415686-19-9 (E)-3-(4-((triisopropylsilyl)oxy)benzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 

Relevant academic research and scientific papers

Total synthesis of nostodione A, a cyanobacterial metabolite

The first total synthesis of the mitotic spindle poison nostodione A is described. The inherent oxidative sensitivity of indoles is utilized for a late introduction of a second carbonyl to the cyclopent[b]indole-2-one system. The tricyclic system is prepared from indole-3-acetic acid and O-silylated 4-ethynylphenol, using a stereoselective intramolecular reductive Heck cyclization as the key transformation.