1415703-68-2Relevant academic research and scientific papers
(E)-N′-(4-Chlorobenzylidene)-,(E)-N′-(4-bromobenzylidene)- and (E)-N′-[4-(diethylamino)benzylidene]-derivatives of 4- hydroxybenzohydrazide
Subashini, Ashokkumar,Ramamurthi, Kandasamy,Stoeckli-Evans, Helen
, p. o408-o412 (2012)
The 4-chloro- [C14H11ClN2O2, (I)], 4-bromo- [C14H10BrN2O2, (II)] and 4-diethyl-amino- [C18H21N3O2, (III)] derivatives of benzyl-idene-4-hy-droxy-benzo-hydrazide, all crystallize in the same space group (P21/c), (I) and (II) also being isomorphous. In all three compounds, the conformation about the C=N bond is E. The molecules of (I) and (II) are relatively planar, with dihedral angles between the two benzene rings of 5.75 (12) and 9.81 (17)°, respectively. In (III), however, the same angle is 77.27 (9)°. In the crystal structures of (I) and (II), two-dimensional slab-like networks extending in the a and c directions are formed via N - H...O and O - H...O hydrogen bonds. The molecules stack head-to-tail via π-π interactions involving the aromatic rings [centroid-centroid distance = 3.7622 (14) A in (I) and 3.8021 (19) A in (II)]. In (III), undulating two-dimensional networks extending in the b and c directions are formed via N - H...O and O - H...O hydrogen bonds. The molecules stack head-to-head via π-π interactions involving inversion-related benzene rings [cen-troid-centroid distances = 3.6977 (12) and 3.8368 (11) A].
Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies
Javaid, Sumaira,Saad, Syed Muhammad,Zafar, Humaira,Malik, Rizwana,Khan, Khalid Mohammed,Iqbal Choudhary,Rahman, Atta-ur
, (2020/02/06)
Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was
