1415718-96-5

Basic information

• Product Name: C₈H₈FNOS
• Synonyms: C₈H₈FNOS
• CAS NO: 1415718-96-5
• Molecular Weight: 185.222
• Mol File: 1415718-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₈H₈FNOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈FNOS(1415718-96-5)
• EPA Substance Registry System: C₈H₈FNOS(1415718-96-5)

Safety Data

• Hazardous Substances Data: 1415718-96-5(Hazardous Substances Data)

Upstream product

• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 796120-91-7 2-fluoro-5-methoxybenzaldehyde oxime 
• 400-92-0 2-fluoro-5-methoxybenzamide 

Downstream Products

• 1415718-98-7 C₁₇H₁₄FNO₂S 

Relevant articles and documents

Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)

NAD(P)H:quinone reductase 1 (QR1) belongs to a class of enzymes called cytoprotective enzymes. It exhibits its cancer protective activity mainly by inhibiting the formation of intracellular semiquinone radicals, and by generating α-tocopherolhydroquinone, which acts as a free radical scavenger. It is therefore believed that QR1 inducers can act as cancer chemopreventive agents. Resveratrol (1) is a naturally occurring stilbene derivative that requires a concentration of 21 μM to double QR1 activity (CD = 21 μM). The stilbene double bond of resveratrol was replaced with a thiadiazole ring and the phenols were eliminated to provide a more potent and selective derivative 2 (CD = 2.1 μM). Optimizing the substitution pattern of the two phenyl rings and the central heterocyclic linker led to a highly potent and selective QR1 inducer 9o with a CD value of 0.087 μM.