1415720-88-5

Basic information

• Product Name: C₁₉H₁₄BrCl₂FN₄S
• Synonyms: C₁₉H₁₄BrCl₂FN₄S
• CAS NO: 1415720-88-5
• Molecular Weight: 500.221
• Mol File: 1415720-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₄BrCl₂FN₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₄BrCl₂FN₄S(1415720-88-5)
• EPA Substance Registry System: C₁₉H₁₄BrCl₂FN₄S(1415720-88-5)

Safety Data

• Hazardous Substances Data: 1415720-88-5(Hazardous Substances Data)

Upstream product

• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 1341205-94-4 4-amino-5-[2-(4-bromophenyl)propan-2-yl]-4H-[1,2,4]-triazole-3-thiol 
• 357915-19-6 α-bromo-(2,4-dichloro-5-fluoro)acetophenone 

Relevant articles and documents

Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines

On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl) propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and LCMS analysis.