1415724-81-0Relevant articles and documents
First synthesis of a pentasaccharide moiety of ganglioside GAA-7 containing unusually modified sialic acids through the use of N -Troc-sialic acid derivative as a key unit
Tamai, Hideki,Ando, Hiromune,Ishida, Hideharu,Kiso, Makoto
supporting information, p. 6342 - 6345 (2013/02/25)
The pentasaccharide part of the potent neuritogenic ganglioside GAA-7 has been synthesized for the first time. The unique branched terminus constituting partially modified sialic acids and N-acetylgalactosamine was successfully established by stereoselective double-sialylation using 8-O-methyl-N-Troc-sialic acid as a donor. The final 4 + 1 coupling reaction provided a high yield of pentasaccharide, which was deprotected to deliver the target molecule.