1415726-87-2Relevant academic research and scientific papers
Organocatalyzed enantioselective decarboxylative stereoablation reaction for the construction of 3,3′-disubstituted oxindoles using β-ketoacids and 3-halooxindoles
Zuo, Jian,Liao, Yu-Hua,Zhang, Xiao-Mei,Yuan, Wei-Cheng
, p. 11325 - 11332 (2013/02/23)
An unprecedented method for the construction of optically active 3,3′-disubstituted oxindoles via an organocatalyzed decarboxylative stereoablation reaction has been developed. We describe the first asymmetric reaction between β-ketoacids and 3-halooxindoles utilizing an organocatalyst. This method allows for the formation of a variety of 3,3′-disubstituted oxindoles bearing a keto-carbonyl group, which are not easily accessible using other methodologies, in moderate to good yields with high enantioselectivities.
