1415800-37-1

Basic information

• Product Name: Bromoacetamido-PEG5 -Azide
• Synonyms: Bromoacetamido-PEG5 -Azide;Bromoacetamido-PEG5-N3
• CAS NO: 1415800-37-1
• Molecular Formula: C14H27BrN4O6
• Molecular Weight: 427.29138
• Mol File: 1415800-37-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Bromoacetamido-PEG5 -Azide(CAS DataBase Reference)
• NIST Chemistry Reference: Bromoacetamido-PEG5 -Azide(1415800-37-1)
• EPA Substance Registry System: Bromoacetamido-PEG5 -Azide(1415800-37-1)

Safety Data

• Hazardous Substances Data: 1415800-37-1(Hazardous Substances Data)

Usage

Description

Bromoacetamido-PEG5-Azide is a heterobifunctional crosslinking reagent that features a bromide (Br) as a highly effective leaving group for nucleophilic substitution reactions. It also contains an azide group that can participate in Click Chemistry reactions with alkyne, BCN, and DBCO, resulting in the formation of a stable triazole linkage. The presence of a PEG (polyethylene glycol) spacer enhances the solubility of the reagent in aqueous media, making it suitable for various applications in different industries.

Uses

Used in Bioconjugation:
Bromoacetamido-PEG5-Azide is used as a crosslinking agent for bioconjugation, particularly in the formation of stable covalent bonds between biomolecules such as proteins, peptides, and other macromolecules. The bromoacetamido group reacts with nucleophilic residues like cysteine, while the azide group can be used for further functionalization through Click Chemistry.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromoacetamido-PEG5-Azide is used as a component in the design of drug delivery systems. The PEG spacer improves the solubility and bioavailability of the drug, while the crosslinking ability of the reagent allows for the creation of stable drug-carrier conjugates, enhancing the overall efficacy and targeting of therapeutic agents.
Used in Materials Science:
In materials science, Bromoacetamido-PEG5-Azide is used as a crosslinking agent for the development of novel biocompatible materials. The reagent can be employed to create stable linkages between different components of a material, improving its mechanical properties and biocompatibility for various applications, such as tissue engineering and implantable devices.
Used in Chemical Synthesis:
Bromoacetamido-PEG5-Azide is used as a synthetic building block in the creation of complex organic molecules and macromolecules. The reagent's dual functional groups allow for versatile synthetic strategies, enabling the formation of a wide range of molecular structures with potential applications in various fields, including pharmaceuticals, agrochemicals, and advanced materials.