1415910-89-2

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 1363375-96-5 benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate 
• 1363375-41-0 ethyl [2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methanesulphonylphenyl)-1H-pyrrol-3-yl]]-acetate 
• 189501-34-6 1-[4-(methylsulfonyl)phenyl]pentane-1,4-dione 
• 1363375-40-9 N-(benzyloxy)carbonyl-2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid 
• 22911-39-3 4-(nitrooxy)butan-1-ol 
• 189501-33-5 1-[4-(methylthio)phenyl]pentane-1,4-dione 
• 189500-90-1 1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole 

Downstream Products

• 1363374-95-1 4-(hydroxy)butyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonyl phenyl)-1H-pyrrol-3-yl]]-acetate 

Relevant academic research and scientific papers

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.