141595-88-2

Upstream product

• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 

Downstream Products

• 283589-06-0 (R)-1-Bromomethyl-2-phenyl-ethylamine; hydrobromide 
• 1433993-19-1 (R)-2-((2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)thio)benzoic acid 
• 1433993-20-4 (R)-2-((2-amino-3-phenylpropyl)thio)benzoic acid 
• 153923-52-5 (R)-3-benzyl-3,4-dihydrobenzo[f][1,4]thiazepin-5(2H)-one 
• 153923-56-9 (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 
• 1433991-86-6 C₂₅H₂₂N₂O₂S₂ 
• 1433993-21-5 (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 
• 1433993-22-6 (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate 1,1-dioxide 
• 1433993-23-7 (R)-3-benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide hydrochloride 
• 1433991-87-7 C₂₅H₂₂N₂O₄S₂ 
• 153923-48-9 (R)-methyl 2-((2-((tert-butoxycarbonyl)amino)-3-phenylpropyl)thio)benzoate 
• 185384-18-3 [(R)-1-Benzyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-carbamic acid tert-butyl ester 
• 714909-31-6 (S)-N¹-((R)-2-Amino-3-phenyl-propyl)-3-phenyl-propane-1,2-diamine 
• 185384-16-1 (2R)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropylamine 

Relevant academic research and scientific papers

SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3)

The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administration of these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof as well as pharmaceutical compositions comprising said compounds as an active ingredient.

Synthesis and biological properties of novel sphingosine derivatives

Sphingosine-1-phosphate (S-1P) derivatives such as threo-(2S,3S)-analogues, which are C-3 stereoisomers of natural erythro-(2S,3R)-S-1P, have been synthesized starting from l-serine or (1S,2S)-2-amino-1-aryl-1,3-propanediols (6). threo-(1S,2R)-2-Amino-1-aryl-3-bromopropanols (HBr salt) have also been prepared from 6. The threo-S-1Ps and the threo-amino-bromide derivatives have shown potent inhibitory activity against Ca2+ ion mobilization in HL60 cells induced by erythro-S-1P, suggesting that these compounds would compete with cell surface EDG/S1P receptors.

Synthesis of C2-symmetric (S,S)-1,4-dibenzyl-DTPA and 1,4-meso-dibenzyl-DTPA via chiral diamines

Novel routes to C2-symmetric (S,S)-1,4-dibenzyl-DTPA and 1,4-meso-dibenzyl-DTPA are described. The methodology utilizes readily available starting materials.