1415977-68-2Relevant academic research and scientific papers
Asymmetric proline-catalyzed addition of aldehydes to 3H-indol-3-ones: Enantioselective synthesis of 2,3-dihydro-1H-indol-3-ones with quaternary stereogenic centers
Rueping, Magnus,Rasappan, Ramesh,Raja, Sadiya
, p. 2296 - 2303 (2012)
The proline-catalyzed addition of various aliphatic aldehydes to sterically hindered 2-aryl-substituted 3H-indol-3-ones affords 2,2-disubstituted 2,3-dihydro-1H-indol-3-one derivatives with excellent enantioselectivities. In addition, the synthesis of a chiral derivative, (S)-2-(2-bromophenyl)-2,3- dihydro-2-(2-hydroxyethyl)-1H-indol-3-one, which can be used as an intermediate for the preparation of the natural product hinckdentine A was accomplished with a high level of enantioselectivity.
