1415980-83-4Relevant academic research and scientific papers
Tandem approach for the synthesis of imidazo[1,2-a]pyridines from alcohols
Ramesha, Ajjahalli B.,Raghavendra, Goravanahalli M.,Nandeesh, Kebbahalli N.,Rangappa, Kanchugarakoppal S.,Mantelingu, Kempegowda
, p. 95 - 100 (2013/02/21)
Propylphosphonic anhydride (T3P) is shown to be an effective and mild reagent for the one-pot synthesis of imidazo[1,2-a]pyridines from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which in turn undergo a three-component reaction with various 2-aminopyridines and isocyanides to afford imidazo[1,2-a]pyridines in excellent yields. T3P acts as an activator for both DMSO in oxidation reaction and the Schiff base in nucleophilic addition reaction with isocyanides.
